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Product Description
– hA2A/hCA XII modulator 1 (compound 14), a triazolopirazine, is a potent hA2A adenosine receptor (hA2AAR) antagonist with Kis of 6.4 nM, 4.819 μM, >30 μM for hA2AAR, hA1AR, hA3AR, respectively. hA2A/hCA XII modulator 1 is a potent human carbonic anhydrase XII (hCA XII) inhibitor with Kis of 6.2 nM, 46 nM, 466 nM, 8.351 μM for hCA XII, hCA II, hCA IX and hCA I, respectively. hA2A/hCA XII modulator 1 has the potential for cancer research[1].
Web ID
– HY-146979
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C24H19N7O4S
References
– [1]Costanza Ceni, et al. Â Discovery of first-in-class multi-target adenosine AÂ 2AÂ receptor antagonists-carbonic anhydrase IX and XII inhibitors. 8-Amino-6-aryl-2-phenyl-1,2,4-triazolo [4,3-a]pyrazin-3-one derivatives as new potential antitumor agents. Eur J Med Chem. 2020 Sep 1;201:112478.
CAS Number
– 2548963-55-7
Molecular Weight
– 501.52
SMILES
– O=C(NC1=CC=C(C2=CN3C(C(N)=N2)=NN(C4=CC=CC=C4)C3=O)C=C1)C5=CC=C(S(=O)(N)=O)C=C5
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Adenosine Receptor;Carbonic Anhydrase
Isoform
– Adenosine A1 receptor (A1R);Adenosine A2A receptor (A2AR);Adenosine A3 receptor (A3R);CA â…¡;CA XII
Pathway
– GPCR/G Protein;Metabolic Enzyme/Protease
Product type
– Reference compound
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