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Products Details
Product Description
– Compound 9 is the most effective against tumor specific Ca ix/ca XII (ki=29.1 and 8.8 nm), so it is possible to evaluate its cytotoxicity and selectivity to HepG-2, HCT-116 and MCF-7 cancer cell lines in vitro, and its IC50 values to tumor cells are 1.78, 1.94 and 3.07, respectively μ M. It showed that it had obvious cytotoxicity.
Web ID
– HY-146819
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C24H21IN4O4S2
References
– [1]Soliman AM,et al. Iodoquinazolinones bearing benzenesulfonamide as human carbonic anhydrase I, II, IX and XII inhibitors: Synthesis, biological evaluation and radiosensitizing activity. Eur J Med Chem. 2020 Aug 15;200:112449.
CAS Number
– 2439165-37-2
Molecular Weight
– 620.48
SMILES
– IC1=CC=C(N=C2SCC(NC3=CC=CC=C3CC)=O)C(C(N2C4=CC=C(S(N)(=O)=O)C=C4)=O)=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Carbonic Anhydrase
Isoform
– CA â…¡;CA â…¨;CA XII
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
