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Products Details
Product Description
– ALDH1A1-IN-3 (compound 57) is an excellent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor with an IC50 value of 0.379 μM. ALDH1A1-IN-3 can effectively improve glucose consumption in HepG2 cells. ALDH1A1-IN-3 can be used for researching glucose metabolism improvement[1].
Web ID
– HY-146240
Shipping
– Room temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C31H36F3N5O4
References
– [1]Ma Z, et al. Design, synthesis of 1,3-dimethylpyrimidine-2,4-diones as potent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with glucose consumption improving activity. Bioorg Chem. 2020 Aug;101:103971.
CAS Number
– 2439177-97-4
Molecular Weight
– 599.64
SMILES
– O=C(N1CCN(CC1)CCC(N(CC2=CC=CC(C(F)(F)F)=C2)C3=CN(C)C(N(C)C3=O)=O)=O)C4=CC=C(C(C)C)C=C4
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– Aldehyde Dehydrogenase (ALDH)
Isoform
– ALDH1
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
