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Products Details
Product Description
– EGFR-IN-58 (Compound 4a) is a potent, ATP-competitive, and selective EGFR inhibitor. EGFR-IN-58 shows potent cytotoxicity against melanoma, colon, and blood cancers[1].
Web ID
– HY-146154
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C31H30FN7O
References
– [1]Ahmed Karam Farag, et al. Design, synthesis, and biological evaluation of pseudo-bicyclic pyrimidine-based compounds as potential EGFR inhibitors. Bioorg Chem. 2022 Sep;126:105918.
Molecular Weight
– 535.61
SMILES
– CN1CCN(CC1)C2=CC=C(C=C2)NC(C3=CN=CN=C3NC4=CC5=C(N(C=C5)CC6=CC(F)=CC=C6)C=C4)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– EGFR
Pathway
– JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
