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Products Details
Product Description
– Chalcones A-N-5 is a trihydroxy chalcone derivative compound. Chalcones A-N-5 doesn’t show cytotoxicity at the concentration lower than 100 µM (with IC50 > 1 mM), but has a significant effect on promoting cell proliferation. Chalcones A-N-5 potentially promotes neuronal cell growth in the damaged brain tissue. Chalcones A-N-5 also inhibits ferroptosis induced by RSL or erastin and reduces the lipid peroxidation levels induced by Aβ1-42 protein aggregation. Chalcones A-N-5 is a promising molecular skeleton candidate for further development of lead compound for in vivo test to research AD[1].
Web ID
– HY-145858
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C21H20N4O4
References
– [1]Liu Y, et al. Rational design, synthesis and activities of hydroxylated chalcones as highly potent dual functional agents against Alzheimer’s disease. Bioorg Chem. 2022;122:105662.
CAS Number
– 2756846-09-8
Molecular Weight
– 392.41
SMILES
– CN(C1=NC=C(C=N1)NC2=CC=C(C=C2)/C=C/C(C3=C(C(O)=C(C=C3)O)O)=O)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Ferroptosis
Pathway
– Apoptosis
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
