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Products Details
Product Description
– J-1063 is a potent, selective and orally active ALK5 inhibitor with an IC50 of 0.039 µM. J-1063 shows anti-fibrotic effect by the inhibition of inflammatory infiltration, collagen deposition, and hepatocytes necrosis. J-1063 has the potential for the research of liver fibrosis[1].
Web ID
– HY-145855
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C24H19N5OS
References
– [1]Zheng GH, et al. The in vitro and in vivo study of a pyrazole derivative, J-1063, as a novel anti-liver fibrosis agent: Synthesis, biological evaluation, and mechanistic analysis. Bioorg Chem. 2022; 122:105715.
CAS Number
– 2374772-46-8
Molecular Weight
– 425.51
SMILES
– CC1=NC(C2=NN(C=C2C3=CC4=C(S3)C=CN=C4)CC(NC5=CC=CC=C5)=O)=CC=C1
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– TGF-β Receptor
Isoform
– ALK5
Pathway
– TGF-beta/Smad
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
