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Products Details
Product Description
– IDO1/TDO-IN-1 (30) is a potent dual IDO1 (uncompetitive, Ki of 0.23 μM) and TDO (competitive, Ki of 0.73 μM) inhibitor. IDO1/TDO-IN-1 (30) significantly promotes cell apoptosis through the potential mitochondria-mediated Bcl-2/Bax pathway[1].
Web ID
– HY-144778
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C21H16O6
References
– [1]Jiangxin Liu, et al. Discovery and biological evaluation of tanshinone derivatives as potent dual inhibitors of indoleamine 2, 3-dioxygenase 1 and tryptophan 2, 3-dioxygenase. Eur J Med Chem. 2022 May 5;235:114294.
CAS Number
– 2379527-72-5
Molecular Weight
– 364.35
SMILES
– CC(OCC1=COC2=C1C(C(C3=C2C=CC4=C3C=CC(C4(C)C)=O)=O)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Bcl-2 Family;Indoleamine 2,3-Dioxygenase (IDO)
Isoform
– IDO1
Pathway
– Apoptosis;Metabolic Enzyme/Protease
Product type
– Reference compound
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