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Products Details
Product Description
– TOPK-p38/JNK-IN-1 (Compound B12) is an orally active TOPK-p38/JNK signaling pathway inhibitor with the IC50 value of 2.14 µM for NO production. TOPK-p38/JNK-IN-1 shows anti-inflammatory activities. TOPK-p38/JNK-IN-1 also inhibits phosphorylate downstream related proteins and avoids degradation of TOPK[1].
Web ID
– HY-144761
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C17H15F3N2O4
References
– [1]Jing Wu, et al. Discovery of novel paeonol-based derivatives against skin inflammation in vitro and in vivo. Journal of Enzyme Inhibition and Medicinal Chemistry, 37:1, 817-831.
CAS Number
– 2745108-35-2
Molecular Weight
– 368.31
SMILES
– O=C(NC1=CC=CC(C(F)(F)F)=C1)NC2=CC(C(C)=O)=C(O)C=C2OC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– JNK
Isoform
– JNK
Pathway
– MAPK/ERK Pathway
Product type
– Reference compound
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