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Products Details
Product Description
– PDGFR-IN-1 (compound 7m) is a potent and orally active PDGFR (platelet-derived growth factor receptor) inhibitor, with IC50 values of 2.4 and 0.9 nM for PDGFRα and PDGFRβ, respectively. PDGFR-IN-1 displays robust antitumor effects and low toxicity, and can be used to study osteosarcoma[1].
Web ID
– HY-144653
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C25H30N8O
References
– [1]Chen X, Liu L, Liu P, et al. Discovery of Potent and Orally Bioavailable Platelet-Derived Growth Factor Receptor (PDGFR) Inhibitors for the Treatment of Osteosarcoma. J Med Chem. 2022;65(7):5374-5391.
CAS Number
– 2644673-07-2
Molecular Weight
– 458.56
SMILES
– CC1=CN=C(N=C1NC2=CC3=C(C=C2)C=NN3)NC4=CC=C(C(OC)=C4)N5CCN(CC5)CC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;PDGFR
Pathway
– Apoptosis;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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