Download Files:
Products Details
Product Description
– NSC81111 is a potent and orally active EGFR-TK inhibitor with an IC50 of 0.15 nM. NSC81111 has anticaner effects[1].
Web ID
– HY-144441
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C19H16O4
References
– [1]Nattanan Jiwacharoenchai, et al. Discovery of potent antiproliferative agents from selected oxygen heterocycles as EGFR tyrosine kinase inhibitors from the U.S. National Cancer Institute database by in silico screening and bioactivity evaluation. Bioorg Med Chem Lett. 2022 Feb 15;58:128524.
CAS Number
– 1678-14-4
Molecular Weight
– 308.33
SMILES
– O=C1C=C(C2=CC=C(OC)C=C2)OC(C3=CC=C(OC)C=C3)=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– EGFR
Pathway
– JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
