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Products Details
Product Description
– ISIS 5132 sodium is a 20-base phosphorothioate oligonucleotide that specifically down-regulates c-raf expression.
Web ID
– HY-153490A
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– N/A
References
– [1]Rudin CM, Holmlund J, Fleming GF, et al. Phase I Trial of ISIS 5132, an antisense oligonucleotide inhibitor of c-raf-1, administered by 24-hour weekly infusion to patients with advanced cancer. Clin Cancer Res. 2001;7(5):1214-1220.|[2]Tolcher AW, Reyno L, Venner PM, et al. A randomized phase II and pharmacokinetic study of the antisense oligonucleotides ISIS 3521 and ISIS 5132 in patients with hormone-refractory prostate cancer. Clin Cancer Res. 2002;8(8):2530-2535.
Molecular Weight
– N/A
SMILES
– [ISIS 5132 (sodium)]
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in H2O
Target
– Raf
Pathway
– MAPK/ERK Pathway
Product type
– Oligonucleotides
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
