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Products Details
Product Description
– PI3Kδ-IN-11 is a highly potent and selective PI3Kδ inhibitor with IC50 value of 27.5 nM. PI3Kδ-IN-11 dose-dependently blocks the activity of PI3K/Akt pathway. PI3Kδ-IN-11 can be used for researching B or T cell-related malignancies[1].
Web ID
– HY-143472
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C27H21N5O
References
– [1]Teng Y, Li X, Ren S, et al. Discovery of novel quinazoline derivatives as potent PI3Kδ inhibitors with high selectivity. Eur J Med Chem. 2020;208:112865.
CAS Number
– 2413257-51-7
Molecular Weight
– 431.49
SMILES
– C=CC(NC1=CC(NC2=C3C=C(C4=CC5=CC=CC=C5N=C4)C=CC3=NC=N2)=CC=C1C)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Akt;Apoptosis;PI3K
Isoform
– PI3Kδ
Pathway
– Apoptosis;PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
