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Products Details
Product Description
– Tubulin polymerization-IN-8 (compound IIc) is a potent inhibitor of tubulin polymerization. Tubulin polymerization-IN-8 concentration-dependently causes cell cycle arrest at the G2/M phase in HCT116 tumor cells, and displays a significant inhibition of tubulin polymerization with an IC50 value of 12.7 μM. Tubulin polymerization-IN-8 has the potential for the research of cancer diseases[ 1].
Web ID
– HY-143447
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C21H24N4O4S
References
– [1] Chen L, et al. Concise synthesis and preliminary biological evaluation of new triazolylthioacetone derivatives bearing pyridine, pyrazine, and 3,4,5-trimethoxybenzyl fragment. Bioorg Med Chem Lett. 2022;66:128721.
CAS Number
– 2768485-08-9
Molecular Weight
– 428.50
SMILES
– COC1=CC(CC2=NN=C(N2N)SCC(C3=CC=C(C=C3)C)=O)=CC(OC)=C1OC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Microtubule/Tubulin
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Reference compound
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