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Products Details
Product Description
– CBP/p300-IN-17 (compound 7) is a potent EP300/CBP HAT inhibitor with IC50s of 0.18, 0.69 µM for HAT EP300 and LK2 H3K27, respectively[1].
Web ID
– HY-143441
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C25H28N4O3
References
– [1]Kanada R, et al. Discovery of EP300/CBP histone acetyltransferase inhibitors through scaffold hopping of 1,4-oxazepane ring. Bioorg Med Chem Lett. 2022 Jun 15;66:128726.
CAS Number
– 2259640-87-2
Molecular Weight
– 432.51
SMILES
– O=C([C@@H]1N(C(C2(C3=CC=C(OC)C=C3)CCCC2)=O)CCC1)NC4=CC=CC5=C4C=NN5
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Histone Acetyltransferase
Isoform
– CBP/p300
Pathway
– Epigenetics
Product type
– Reference compound
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