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Products Details
Product Description
– BRD4 D1-IN-2 (compound 26) is a potent and selective BRD4 D1 inhibitor (IC50<0.092 µM). BRD4 D1-IN-2 has 15 nM affinity against BRD4 D1 and over 500-fold selectivity against BRD2 D1 and BRD4 D2 via ITC[1].
Web ID
– HY-142705
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C33H39F3N6O
References
– [1]Cui H, et al. A Structure-based Design Approach for Generating High Affinity BRD4 D1-Selective Chemical Probes. J Med Chem. 2022;65(3):2342-2360.
CAS Number
– 2863687-22-1
Molecular Weight
– 592.70
SMILES
– CC(C1=CC=C(C(OC2=NC(C3=C(N=CN3C4CCN(CC4)CCN(C)C)C5=CC=C(C=C5)C(F)(F)F)=CC=N2)=C1)C)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Epigenetic Reader Domain
Isoform
– BRD4
Pathway
– Epigenetics
Product type
– Reference compound
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