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Products Details
Product Description
– Beauverolide Ja, a cyclotetradepsipeptide, is a potent calmodulin (CaM) inhibitor with a Kd of 0.078 μM and a Ki of 0.39 μM for Ca2+-CaM. Beauverolide Ja is a secondary metabolite of Isaria fumosorosea[1].
Web ID
– HY-142087
Shipping
– Room temperature
Molecular Formula
– C35H46N4O5
References
– [1]Abraham Madariaga-Mazón, et al. Potent anti-calmodulin activity of cyclotetradepsipeptides isolated from Isaria fumosorosea using a newly designed biosensor. Nat Prod Commun. 2015 Jan;10(1):113-6.|[2]Qunfang Weng, et al. Secondary Metabolites and the Risks of <i>Isaria fumosorosea</i> and <i>Isaria farinose</i>. Molecules. 2019 Feb 13;24(4):664.
CAS Number
– 76265-41-3
Molecular Weight
– 602.76
SMILES
– O=C(N[C@H](C(N[C@](C(OC(CC(N1)=O)C(C)CCCC)=O)([H])[C@@H](C)CC)=O)CC2=CC=CC=C2)[C@@H]1CC3=CNC4=CC=CC=C34
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Calmodulin;Endogenous Metabolite
Isoform
– Microbial Metabolite
Pathway
– Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease
Product type
– Reference compound
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