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Tegaserod (maleate)
$32 – $260
Products Details
Product Description
– Tegaserod maleate (SDZ-HTF-919) is an orally active serotonin receptor 4 (HTR4; 5-HT4R) agonist and a 5-HT2B receptor antagonist. Tegaserod maleate has pKis of 7.5, 8.4 and 7.0 for human recombinant 5-HT2A, 5-HT2B and 5-HT2C receptors, respectively. Tegaserod maleate causes tumor cell apoptosis, blunts PI3K/Akt/mTOR signaling and decreases S6 phosphorylation. Tegaserod maleate has anti-tumor activity and has the potential for irritable bowel syndrome (IBS) research[1][2][3].
Web ID
– HY-14153A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C20H27N5O5
References
– [1]M D Crowell, et al. The effects of tegaserod, a 5-HT receptor agonist, on gastric emptying in a murine model of diabetes mellitus. Neurogastroenterol Motil. 2005 Oct;17(5):738-43.|[2]D T Beattie, et al. The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo. Br J Pharmacol. 2004 Nov;143(5):549-60.|[3]Wei Liu, et al. Repurposing the serotonin agonist Tegaserod as an anticancer agent in melanoma: molecular mechanisms and clinical implications. J Exp Clin Cancer Res. 2020 Feb 21;39(1):38.
CAS Number
– 189188-57-6
Molecular Weight
– 417.46
Compound Purity
– 99.93
SMILES
– O=C(O)/C=CC(O)=O.COC1=CC=C(NC=C2/C=N/NC(NCCCCC)=N)C2=C1
Clinical Information
– Launched
Research Area
– Metabolic Disease; Neurological Disease
Solubility
– DMSO : ≥ 35 mg/mL|H2O : 1 mg/mL (ultrasonic)
Target
– 5-HT Receptor;Apoptosis
Isoform
– 5-HT2 Receptor;5-HT4 Receptor
Pathway
– Apoptosis;GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
