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Rimonabant
$32 – $240
Products Details
Product Description
– Rimonabant (SR141716) is a highly potent, brain penetrated and selective central cannabinoid receptor (CB1) antagonist with a Ki of 1.8 nM. Rimonabant (SR141716) also inhibits Mycobacterial membrane protein Large 3 (MMPL3).
Web ID
– HY-14136
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C22H21Cl3N4O
Citations
– Autophagy. 2021 Nov;17(11):3592-3606.|Cell. 2019 Jan 24;176(3):636-648.e13. |Structure. 2022 Aug 7;S0969-2126(22)00278-7.|Cancers (Basel). 2021 Jan 18;13(2):330.|Neuroscience. 2019 Feb 19. pii: S0306-4522(19)30117-4.Â
References
– [1]Seely KA, Brents LK, Franks LN, Rajasekaran M, Zimmerman SM, Fantegrossi WE, Prather PL.
AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: Implications for opioid/cannabinoid interaction studies.
Neuropharmacology. 2012 Oct;63(5):905-15.|[2]Zhang B, et al. Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target. Cell. 2019 Jan 24;176(3):636-648.e13.|[3]Erdozain, A. M. et al. The inverse agonist effect of rimonabant on G protein activation is not mediated by the cannabinoid CB1 receptor: Evidence from postmortem human brain Biochemical Pharmacology (2012), 83(2), 260-268.|[4]Leite, C.E., et al. Rimonabant: An antagonist drug of the endocannabinoid system for the treatment of obesity. Pharmacol Rep 61 217-224 (2009).
CAS Number
– 168273-06-1
Molecular Weight
– 463.79
Compound Purity
– 99.41
SMILES
– ClC1=CC=C(C=C1)C2=C(C(C(NN3CCCCC3)=O)=NN2C4=CC=C(C=C4Cl)Cl)C
Clinical Information
– Launched
Research Area
– Infection; Metabolic Disease; Cancer
Solubility
– DMSO : 125 mg/mL (ultrasonic)
Target
– Bacterial;Cannabinoid Receptor
Isoform
– CB1
Pathway
– Anti-infection;GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
