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Products Details
Product Description
– JNK3 inhibitor-1 is a potent and selective JNK3 inhibitor (IC50 = 0.005 μM). JNK3 inhibitor-1 is orally bioavailable and brain penetrant.
Web ID
– HY-139624
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C21H17ClFN5O2S
References
– [1]Feng Y, et al. N-Aromatic-Substituted Indazole Derivatives as Brain-Penetrant and Orally Bioavailable JNK3 Inhibitors. ACS Med Chem Lett. 2021 Sep 21;12(10):1546-1552.
CAS Number
– 2622877-97-6
Molecular Weight
– 457.91
SMILES
– O=C(C1=CC(N2N=CC3=CC(NC4=C(F)C=CC=C4Cl)=C(C)N=C32)=CS1)NC5COC5
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– 10 mM in DMSO
Target
– JNK
Pathway
– MAPK/ERK Pathway
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
