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GK563
$218
Only 1000 item(s) left in stock.
Products Details
Product Description
– GK563 is a selective Ca2+-independent phospholipase A2 (GVIA iPLA2) inhibitor with an IC50 value of 1 nM. GK563 is 22000 times more active against GVIA iPLA2 than GIVA cPLA2. GK563 reduces β-cell apoptosis induced by proinflammatory cytokines, raising the possibility that it can be beneficial in countering autoimmune diseases, such as type 1 diabetes[1].
Web ID
– HY-138990
Shipping
– Room temperature
Molecular Formula
– C16H22O2
References
– [1]Dedaki C, et al. β-Lactones: A Novel Class of Ca2+-Independent Phospholipase A2 (Group VIA iPLA2) Inhibitors with the Ability To Inhibit β-Cell Apoptosis. J Med Chem. 2019 Mar 28;62(6):2916-2927.
CAS Number
– 2351820-19-2
Molecular Weight
– 246.34
SMILES
– CCC[C@H]1[C@@H](C(O1)=O)CCCCC2=CC=CC=C2
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Phospholipase
Pathway
– Apoptosis;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
