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Products Details
Product Description
– ADTL-EI1712 is a potent, orally active, and selective dual-target inhibitor of ERK1 and ERK5, inhibition rates of ERK1/5 at 1 μM are 93.54% and 89.35%, respectively. ADTL-EI1712 can induce regulated cell death, a form of cell death that relies on the activation of genetically encoded machinery, to overcome compensatory mechanism in specific cancer cells in vitro and in vivo[1].
Web ID
– HY-138215
Shipping
– Room temperature
Molecular Formula
– C22H18Cl2N4O2S2
References
– [1]Wang G, et al. Discovery of a Novel Dual-Target Inhibitor of ERK1 and ERK5 That Induces Regulated Cell Death to Overcome Compensatory Mechanism in Specific Tumor Types. J Med Chem. 2020 Apr 23;63(8):3976-3995.
CAS Number
– 2414916-45-1
Molecular Weight
– 505.44
SMILES
– O=C(C1=C(NC(C2=CC=CC=C2Cl)=O)SC3=C1CCN(C(NC4=CC=CC=C4Cl)=S)C3)N
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– ERK
Pathway
– MAPK/ERK Pathway;Stem Cell/Wnt
Product type
– Reference compound
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