Download Files:
Sitagliptin (phosphate monohydrate)
$66 – $79
Products Details
Product Description
– Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) is a potent inhibitor of DPP4 with an IC50 of 19 nM in Caco-2 cell extracts[1].
Web ID
– HY-13749B
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C16H20F6N5O6P
Citations
– Biomed Pharmacother. 2023 Mar 24;162:114555.|bioRxiv. 2023 Nov 4.|Biochem Pharmacol. 2023 Oct 5:115846.|Cell Death Dis. 2021 Oct 11;12(10):928.|Front Oncol. 24 September 2021.|iScience. 2023 Feb.|J Biol Chem. 2018 Dec 7;293(49):18864-18878. |J Sep Sci. 2021 Oct 28.|Korean J Physiol Pharmacol. 2021 Sep 1;25(5):425-437.|Neurol Res. 2018 Sep;40(9):736-743.|Nutr Neurosci. 2018 Apr 26:1-17.|Oxid Med Cell Longev. 2019 Nov 15;2019:6181754.|Oxid Med Cell Longev. 2022 May 17;2022:2586305.|Sci Rep. 2019 Mar 11;9(1):4074.
References
– [1]Kim, S.J., et al., Dipeptidyl peptidase IV inhibition with MK0431 improves islet graft survival in diabetic NOD mice partially via T-cell modulation. Diabetes, 2009. 58(3): p. 641-51.|[2]Beconi, M.G., et al. Disposition of the dipeptidyl peptidase 4 inhibitor sitagliptin in rats and dogs. Drug Metab Dispos, 2007. 35(4): p. 525-32.|[3]Kim, S.J., et al., Inhibition of dipeptidyl peptidase IV with sitagliptin (MK0431) prolongs islet graft survival in streptozotocin-induced diabetic mice. Diabetes, 2008. 57(5): p. 1331-9.|[4]Thomas, L., et al. (R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylm ethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of acti|[5]Sangle, G.V., et al., Novel biological action of the dipeptidylpeptidase-IV inhibitor, sitagliptin, as a GLP-1 secretagogue. Endocrinology, 2012. 153(2): p. 564-73.
CAS Number
– 654671-77-9
Molecular Weight
– 523.32
Compound Purity
– 99.49
SMILES
– [H]O[H].O=C(N1CC2=NN=C(C(F)(F)F)N2CC1)C[C@H](N)CC3=CC(F)=C(F)C=C3F.O=P(O)(O)O
Clinical Information
– Launched
Research Area
– Metabolic Disease
Solubility
– H2O : ≥ 33 mg/mL
Target
– Autophagy;Dipeptidyl Peptidase
Isoform
– DPP-4
Pathway
– Autophagy;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
