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Sivopixant
$180 – $450
Products Details
Product Description
– Sivopixant (S-600918) is a potent and selective P2X3 receptor antagonist (P2X3 IC50=4.2 nM; P2X2/3 IC50=1100 nM). Sivopixant shows strong analgesic effect[1].
Web ID
– HY-137451
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C25H22ClN5O5
References
– [1]Kai H, et al. Discovery of clinical candidate Sivopixant (S-600918): Lead optimization of dioxotriazine derivatives as selective P2X3 receptor antagonists [published online ahead of print, 2021 Sep 26]. Bioorg Med Chem Lett. 2021;52:128384.
CAS Number
– 2414285-40-6
Molecular Weight
– 507.93
Compound Purity
– 98.64
SMILES
– O=C(N(C1=O)C[C@H](C)C(O)=O)N/C(N1CC2=CC=C(C=C2)Cl)=NC3=CC=C(C=C3)OC4=CC=CC=N4
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– P2X Receptor
Isoform
– P2X3 Receptor
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
