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Firazorexton
$580 – $2,080
Products Details
Product Description
– Firazorexton (TAK-994 free base) is an oral active orexin type 2 receptor (OX2R) agonist (EC50=19 nM). Firazorexton has the potential to improve narcolepsy-like symptoms. Firazorexton promotes wakefulness in normal mice and improves wake fragmentation and cataplexy-like episodes in a mouse model of narcolepsy. However, Firazorexton was ineffective in OX2R knockout mice[1].
Web ID
– HY-137440
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C22H25F3N2O4S
References
– [1]Ishikawa T, et al. TAK-994, a Novel Orally Available Brain-Penetrant Orexin 2 Receptor-Selective Agonist, Suppresses Fragmentation of Wakefulness and Cataplexy-Like Episodes in Mouse Models of Narcolepsy. J Pharmacol Exp Ther. 2023 Jun;385(3):193-204.
CAS Number
– 2274802-95-6
Molecular Weight
– 470.51
Compound Purity
– 99.94
SMILES
– O=C(N(CC1)[C@H]([C@H]1N[S](C)(=O)=O)CC(C=CC=C2C3=CC(F)=CC(F)=C3)=C2F)C(C)(O)C
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 250 mg/mL (ultrasonic)
Target
– Orexin Receptor (OX Receptor)
Isoform
– OX2 Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
