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Raloxifene (hydrochloride)
$66 – $106
Products Details
Product Description
– Raloxifene hydrochloride (Keoxifene hydrochloride) is a second generation selective and orally active estrogen receptor modulator. Raloxifene hydrochloride produces estrogen-agonistic effects on bone and lipid metabolism and estrogen-antagonistic effects on uterine endometrium and breast tissue[1].
Web ID
– HY-13738A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C28H28ClNO4S
Citations
– Eberhard Karls Universität Tübingen. 2021 Aug.|Free Radic Biol Med. 2017 Apr 10;108:404-417.|Med Sci Monit. 2019 Apr 29;25:3146-3153.|Oxid Med Cell Longev. 2021 Mar 20;2021:6699054.|PLoS Negl Trop Dis. 2019 Aug 20;13(8):e0007681. |Research Square Preprint. 2020 Nov 4;rs.3.rs-100914.|Viruses. 2021 Jun 28;13(7):1255.|ACS Omega. 2023 Jun 14.|J Pharmaceut Biomed. 2020, 113870.
References
– [1]Yang, N.N., et al., Estrogen and raloxifene stimulate transforming growth factor-beta 3 gene expression in rat bone: a potential mechanism for estrogen- or raloxifene-mediated bone maintenance. Endocrinology, 1996. 137(5): p. 2075-84.|[2]Obach, R.S., Potent inhibition of human liver aldehyde oxidase by raloxifene. Drug Metab Dispos, 2004. 32(1): p. 89-97.|[3]Sato, M., M.K. Rippy, and H.U. Bryant, Raloxifene, tamoxifen, nafoxidine, or estrogen effects on reproductive and nonreproductive tissues in ovariectomized rats. FASEB J, 1996. 10(8): p. 905-12.|[4]Black, L.J., et al., Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats. J Clin Invest, 1994. 93(1): p. 63-9.|[5]Shibata MA, et al. Raloxifene inhibits tumor growth and lymph node metastasis in a xenograft model of metastatic mammary cancer.BMC Cancer. 2010 Oct 19;10:566.
CAS Number
– 82640-04-8
Molecular Weight
– 510.04
Compound Purity
– 99.91
SMILES
– O=C(C1=C(C2=CC=C(O)C=C2)SC3=CC(O)=CC=C31)C4=CC=C(OCCN5CCCCC5)C=C4.Cl
Clinical Information
– Launched
Research Area
– Endocrinology; Cancer
Solubility
– DMSO : 33.33 mg/mL (ultrasonic)|H2O : 1 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Autophagy;Estrogen Receptor/ERR
Pathway
– Autophagy;Vitamin D Related/Nuclear Receptor
Product type
– Natural Products
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