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PJ34 (hydrochloride)
$37 – $288
Products Details
Product Description
– PJ34 hydrochloride is an inhibitor of PARP1/2 with IC50 of 110 nM and 86 nM, respectively.
Web ID
– HY-13688
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C17H18ClN3O2
Citations
– Acta Biomater. 2022 May 25;S1742-7061(22)00310-5.|Anim Cells Syst. 03 Aug 2022.|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.|Sci Rep. 2017 May 23;7(1):2268.|Apoptosis. 2021 Sep 28.|bioRxiv. 2023 Oct 4.|Cancer Lett. 2021 Jul 3;S0304-3835(21)00325-6.|Free Radic Biol Med. 2021 Dec 16;S0891-5849(21)01112-6.|J Virol. 2021 May 26;JVI0076021.|Nottingham Trent University. 2023 Sep 12.|Part Fibre Toxicol. 2020 Jun 8;17(1):23. |Patent. US20180263995A1.|Proc Natl Acad Sci U S A. 2023 Mar 28;120(13):e2213857120.|Regen Ther. 2023 Dec, 24, 592-601.|Research Square Print. 2022.|Sci Signal. 2023 Jan 17;16(768):eabh1083.
References
– [1]Haddad M, et al. Anti-inflammatory effects of PJ34, a poly(ADP-ribose) polymerase inhibitor, in transient focal cerebral ischemia in mice. Br J Pharmacol. 2006 Sep;149(1):23-30.|[2]Iwashita A, et al. A novel and potent poly(ADP-ribose) polymerase-1 inhibitor, FR247304 (5-chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), attenuates neuronal damage in in vitro and in vivo models of cerebral ischemia. J Ph|[3]Diani-Moore S, et al. NAD+ loss, a new player in AhR biology: prevention of thymus atrophy and hepatosteatosis by NAD+ repletion. Sci Rep. 2017 May 23;7(1):2268.
CAS Number
– 344458-15-7
Molecular Weight
– 331.80
Compound Purity
– 99.91
SMILES
– O=C(NC(C=C1C2=C3C=CC=C2)=CC=C1NC3=O)CN(C)C.Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : 50 mg/mL (ultrasonic)
Target
– PARP
Isoform
– PARP;PARP1;PARP2
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
