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Products Details
Product Description
– RP101442, an active metabolite of Ozanimod, is a selective, potent S1PR1 (sphingosine-1-phosphate receptor 1) agonist, with EC50s of 2.6 nM and 171 nM for S1PR1 and S1PR5, respectively[1].
Web ID
– HY-136577
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C23H22N4O3
References
– [1]Tran JQ, et al. Cardiac Safety of Ozanimod, a Novel Sphingosine-1-Phosphate Receptor Modulator: Results of a Thorough QT/QTc Study. Clin Pharmacol Drug Dev. 2018;7(3):263-276.
CAS Number
– 1306761-08-9
Molecular Weight
– 402.45
SMILES
– CC(N[C@H]1CCC2=C1C=CC=C2C3=NOC(C4=CC=C(OC(C)C)C(C#N)=C4)=N3)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Drug Metabolite;LPL Receptor
Isoform
– S1PR1;S1PR5
Pathway
– GPCR/G Protein;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
