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Chrysophanol
$40 – $60
Products Details
Product Description
– Chrysophanol (Chrysophanic acid) is a natural anthraquinone, which inhibits EGF-induced phosphorylation of EGFR and suppresses activation of AKT and mTOR/p70S6K.
Web ID
– HY-13595
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C15H10O4
References
– [1]Lee MS, et al. Chrysophanic acid blocks proliferation of colon cancer cells by inhibiting EGFR/mTOR pathway. Phytother Res. 2011 Jun;25(6):833-7.|[2]Lim H, et al. Chrysophanic Acid Suppresses Adipogenesis and Induces Thermogenesis by Activating AMP-Activated Protein Kinase Alpha In vivo and In vitro. Front Pharmacol. 2016 Dec 8;7:476.
CAS Number
– 481-74-3
Molecular Weight
– 254.24
Compound Purity
– 99.77
SMILES
– O=C1C2=C(C=CC=C2O)C(C3=CC(C)=CC(O)=C13)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMF : 4 mg/mL (ultrasonic)|DMSO : 2 mg/mL (ultrasonic)|H2O : 0.67 mg/mL (ultrasonic)
Target
– EGFR
Isoform
– EGFR/ErbB1/HER1
Pathway
– JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Natural Products
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
