Download Files:
Betamethasone-d5-1
$3,598
Only 1000 item(s) left in stock.
Products Details
Product Description
– Betamethasone-d5-1 is deuterium labeled Betamethasone. Betamethasone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities. Betamethasone accelerates fetal lung maturation and induces gene expression and apoptosis[1][2][3][4].
Web ID
– HY-13570S1
Shipping
– Room temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C22H24D5FO5
References
– [1]Hofmann TH, et, al. Various glucocorticoids differ in their ability to induce gene expression, apoptosis and to repress NF-kappaB-dependent transcription. FEBS Lett. 1998 Dec 28;441(3):441-6.|[2]Kubin ME, et, al. Clinical Efficiency of Topical Calcipotriol/Betamethasone Treatment in Psoriasis Relies on Suppression of the Inflammatory TNFα – IL-23 – IL-17 Axis. Acta Derm Venereol. 2017 Apr 6;97(4):449-455.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[4]Schwab M, et, al. Effects of betamethasone administration to the fetal sheep in late gestation on fetal cerebral blood flow. J Physiol. 2000 Nov 1;528(Pt 3):619-32.|[5]Xie W, et, al. Betamethasone affects cerebral expressions of NF-kappaB and cytokines that correlate with pain behavior in a rat model of neuropathy. Ann Clin Lab Sci. Winter 2006;36(1):39-46.
CAS Number
– 2244574-92-1
Molecular Weight
– 397.49
SMILES
– C[C@@]12[C@](C[C@H](C)[C@]2(O)C(CO)=O)([H])[C@]3([H])CC([2H])C4=C([2H])C(C=C[C@]4(C)[C@@]3(F)[C@](O)([2H])C1([2H])[2H])=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology; Endocrinology; Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Glucocorticoid Receptor;Isotope-Labeled Compounds
Pathway
– Apoptosis;Immunology/Inflammation;Others;Vitamin D Related/Nuclear Receptor
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
