Download Files:
Dot1L-IN-4
$238 – $4,200
Products Details
Product Description
– Dot1L-IN-4 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 SPA DOT1L of 0.11 nM[1].
Web ID
– HY-135127
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C28H27ClF2N8O5S
References
Р[1]Fr̩d̩ric Stauffer, et al. New Potent DOT1L Inhibitors for in Vivo Evaluation in Mouse. ACS Med. Chem. Lett. 2019, 10, 12, 1655-1660.
CAS Number
– 2565705-02-2
Molecular Weight
– 661.08
Compound Purity
– 99.60
SMILES
– O=S(C1=CC=C(N[C@H](C2=NC=CC=C2Cl)C3=C4OC(F)(F)OC4=CC=C3)C(NC5=NC(OC)=NC(N6CCNCC6)=N5)=C1)(C)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : ≥ 220 mg/mL
Target
– Histone Methyltransferase
Isoform
– DOT1L
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
