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Ethacizine (hydrochloride)
$140 – $1,200
Products Details
Product Description
– Ethacizine hydrochloride (Ethacizin; NIK-244) is a longer-lasting Class Ic antiarrhythmic agent than Flecainide[1]. Ethacizine hydrochloride (Ethacizin; NIK-244) inhibits the depolarizing current responsible for the intraatrial and His-Purkinje-ventricular conduction[2].
Web ID
– HY-135121
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C22H28ClN3O3S
References
– [1]Sugiyama A, et al. Comparison of cardiovascular effects of a novel class Ic antiarrhythmic agent, NIK-244, with those of flecainide in isolated canine heart preparations cross-circulated with a donor dog.Jpn J Pharmacol. 1991 May;56(1):1-12.|[2]Satoh H, et al. An electrophysiological comparison of a novel class Ic antiarrhythmic agent, NIK-244 (ethacizin) and flecainide in canine ventricular muscle.Br J Pharmacol. 1989 Nov;98(3):827-32.Med Chem. 2019 Nov 6:115132.
CAS Number
– 57530-40-2
Molecular Weight
– 449.99
Compound Purity
– 98.48
SMILES
– O=C(OCC)NC(C=C1N2C(CCN(CC)CC)=O)=CC=C1SC3=C2C=CC=C3.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– Sodium Channel
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
