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EC144
$180 – $1,400
Products Details
Product Description
– EC144 is a potent and selective inhibitor of heat shock protein 90 (Hsp90) with an IC50 of 1.1 nM. EC144 inhibits tumor growth and causes partial tumor regressions. EC144 has the potential for the research of cancer diseases[1]. EC144 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Web ID
– HY-13479
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture and light)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C21H24ClN5O2
References
– [1]Shi J, et al. EC144 is a potent inhibitor of the heat shock protein 90. J Med Chem. 2012;55(17):7786-7795.
CAS Number
– 911397-80-3
Molecular Weight
– 413.90
Compound Purity
– 99.58
SMILES
– CC(O)(C)CC#CC1=CN(CC2=NC=C(C)C(OC)=C2C)C3=NC(N)=NC(Cl)=C31
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 66.67 mg/mL (ultrasonic)
Target
– HSP
Pathway
– Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
