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Products Details
Product Description
– 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate is an irreversible CYP2A6 inhibitor with IC50s of 8.64 μM and 22.3 μM with pre-incubation and co-incubaition, respectively. 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate also inhibits MAO-A and MAO-B with IC50s of 60.2 and 38.6 μM, respectively[1].
Web ID
– HY-134664
Shipping
– Room temperature
Molecular Formula
– C21H26O8
References
– [1]Prasopthum A, et al. Inhibition effects of Vernonia cinerea active compounds against cytochrome P450 2A6 and human monoamine oxidases, possible targets for reduction of tobacco dependence. Drug Metab Pharmacokinet. 2015 Apr;30(2):174-81.
CAS Number
– 67667-71-4
Molecular Weight
– 406.43
SMILES
– CC(OCC1=C([C@H](C[C@H]2C)OC(C(C)=C)=O)/C(OC1=O)=C[C@](O[C@]23O)(CC3)C)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Cytochrome P450;Monoamine Oxidase
Pathway
– Metabolic Enzyme/Protease;Neuronal Signaling
Product type
– Reference compound
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