Download Files:
Products Details
Product Description
– SCH-202676 is an allosteric modulator of G protein-coupled receptors (GPCRs) and adenosine receptor (AR). SCH-202676 has antiviral activity and inhibits 3CLpro in a time-dependent manner with an IC50 value of 0.655 µM[1][2][3][4].
Web ID
– HY-133862
Shipping
– Room temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C15H13N3S
References
– [1]Ren P, et al. Discovery, synthesis and mechanism study of 2,3,5-substituted [1,2,4]-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2. Eur J Med Chem. 2023 Jan 18;249:115129.|[2]Lewandowicz AM, et al. The ‘allosteric modulator’ SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms. Br J Pharmacol. 2006 Feb;147(4):422-9.|[3]Fawzi A B, et al. SCH-202676: an allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors[J]. Molecular Pharmacology, 2001, 59(1): 30-37.|[4]Gao ZG, et al. Effects of the allosteric modulator SCH-202676 on adenosine and P2Y receptors. Life Sci. 2004 May 7;74(25):3173-80.
CAS Number
– 70375-43-8
Molecular Weight
– 267.35
SMILES
– C/N=C1N=C(C2=CC=CC=C2)N(C3=CC=CC=C3)S/1
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Adenosine Receptor;G protein-coupled Bile Acid Receptor 1;Influenza Virus
Isoform
– Adenosine A3 receptor (A3R)
Pathway
– Anti-infection;GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
