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BTK inhibitor 18
$920 – $7,500
Products Details
Product Description
– BTK inhibitor 18 is a potent, selective,orally active and covalent Btk inhibitor with a IC50 of 142 nM. BTK inhibitor 18 has anti-inflammatory activities[1].
Web ID
– HY-132196
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C29H25N5O4S2
References
– [1]Mark S Tichenor, et al. Discovery of a Potent and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase with Oral Anti-Inflammatory Activity. ACS Med Chem Lett. 2021 Apr 5;12(5):782-790.
Molecular Weight
– 571.67
SMILES
– CC1=CC(OC2=CC=CC=C2)=CC=C1N3C4=C5C(NC3=O)=C(C(N[C@H]6CN(C(C=C)=O)CC6)=O)SC5=NC=C4.[*S]
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Btk
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
