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Products Details
Product Description
– β-Naphthoflavone-CH2-OH (β-NF-CH2-OH) is a ligand for arylhydrocarbon receptor (AhR) E3 ligase. β-Naphthoflavone-CH2-OH can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs (e.g., β-naphthoflavone-JQ1) that recruit the AhR E3 ligase complex by incorporating AhR ligands into chimeric molecules. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins [1].
Web ID
– HY-130269
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C20H14O3
References
– [1]Ohoka N, et al. Development of Small Molecule Chimeras That Recruit AhR E3 Ligase to Target Proteins. ACS Chem Biol. 2019 Oct 16.
CAS Number
– 2752755-32-9
Molecular Weight
– 302.32
SMILES
– O=C1C=C(C2=CC=C(CO)C=C2)OC3=C1C4=CC=CC=C4C=C3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Ligands for E3 Ligase
Isoform
– IAP
Pathway
– PROTAC
Product type
– Reference compound
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