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Product Description
– 3,3′-Diiodo-L-thyronine-13C6 is the 13C labeled 3,3′-Diiodo-L-thyronine[1]. 3,3′-Diiodo-L-thyronine (3,3′-T2) is an endogenous metabolite of thyroid hormone. 3,3′-Diiodo-L-thyronine significantly enhances COX activity[2][3].
Web ID
– HY-129974S
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C9 13C6H13I2NO4
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Lorenzini L, et al. Assay of Endogenous 3,5-diiodo-L-thyronine (3,5-T2) and 3,3′-diiodo-L-thyronine (3,3′-T2) in Human Serum: A Feasibility Study. Front Endocrinol (Lausanne). 2019 Feb 19;10:88.|[3]Lanni A, et al. Rapid stimulation in vitro of rat liver cytochrome oxidase activity by 3,5-diiodo-L-thyronine and by 3,3′-diiodo-L-thyronine. Mol Cell Endocrinol. 1994 Feb99(1):89-94.|[4]Chen X, et al. Simultaneous quantification of T4, T3, rT3, 3,5-T2 and 3,3′-T2 in larval zebrafish (Danio rerio) as a model to study exposure to polychlorinated biphenyls. Biomed Chromatogr. 2018 Jun32(6):e4185.
CAS Number
– 1217459-13-6
Molecular Weight
– 531.03
SMILES
– IC(C=C(C=C1)C[C@H](N)C(O)=O)=C1O[13C]2=[13CH][13C](I)=[13C]([13CH]=[13CH]2)O
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– COX;Endogenous Metabolite
Pathway
– Immunology/Inflammation;Metabolic Enzyme/Protease
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
