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BI 653048
$450 – $14,800
Products Details
Product Description
– BI 653048 is a selective and orally active nonsteroidal glucocorticoid (GC) agonist with an IC50 value of 55 nM[1]. BI 653048 inhibits CP1A2, CYP2D6, CYP2C9, CYP2C19 and CYP3A4 isoforms’ activity and reduces affinity for the hERG ion channel (IC50>30 μM)[2]. BI 653048 is extracted from patent WO2005028501A1 (Compound 103), is also a HCV NS3 protease inhibitor that can reduce viral loads infected with the hepatitis C virus[3].
Web ID
– HY-12946
Shipping
– Room temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C23H25F4N3O4S
References
– [1]Harcken C, et al. Optimization of drug-like properties of nonsteroidal glucocorticoid mimetics and identification of a clinical candidate.ACS Med Chem Lett. 2014 Nov 20;5(12):1318-23.|[2]Reeves JT, et al. Development of a large scale asymmetric synthesis of the glucocorticoid agonist BI 653048 BS H3PO4.J Org Chem. 2013 Apr 19;78(8):3616-35.|[3]Montse Llinas-Brunet, et al. Latest bibliographic data on file with the International Bureau
CAS Number
– 1198784-72-3
Molecular Weight
– 515.52
SMILES
– O=C(N)C1=CC(F)=CC=C1C(C)(C)C[C@@](O)(CC(N2)=CC3=C2C=NC(S(=O)(CC)=O)=C3)C(F)(F)F
Clinical Information
– Phase 1
Research Area
– Infection; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Cytochrome P450;Glucocorticoid Receptor;HCV Protease
Isoform
– CYP1;CYP2;CYP3
Pathway
– Anti-infection;Immunology/Inflammation;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
