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BOP (sodium)
$695
Only 1000 item(s) left in stock.
Products Details
Product Description
– BOP sodium is a potent and selective dual α9β1/α4β1 integrin inhibitor with Kd values in the picomolar range. BOP sodium shows the rapid and preferential mobilization of hematopoietic stem cell (HSC) and progenitors. BOP sodium has little inhibitory activity on α4β7, α1β1, α2β1, and α5β1, αIIBβ3 integrins[1][2].
Web ID
– HY-129453
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Applications
– COVID-19-immunoregulation
Molecular Formula
– C25H28N3NaO7S
References
– [1]R Blake Pepinsky, et al. Comparative assessment of the ligand and metal ion binding properties of integrins alpha9beta1 and alpha4beta1. Biochemistry. 2002 Jun 4;41(22):7125-41.|[2]Benjamin Cao, et al. Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist. Nat Commun. 2016 Mar 15;7:11007.
CAS Number
– 1947348-42-6
Molecular Weight
– 537.56
Compound Purity
– 99.11
SMILES
– O=C(O[Na])[C@H](CC1=CC=C(OC(N2CCCC2)=O)C=C1)NC([C@H]3N(S(=O)(C4=CC=CC=C4)=O)CCC3)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– H2O : 125 mg/mL (ultrasonic)
Target
– Integrin
Isoform
– α4β1;α9β1
Pathway
– Cytoskeleton
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
