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Products Details
Product Description
– Akt1/Akt2-IN-2 (compound 7) is an allosteric dual Akt1 and Akt2 inhibitor (IC50=138 nM and 212 nM, respectively). Akt1/Akt2-IN-2 increases activity of caspase-3, and inhibits viability of a number of tumor cells[1].
Web ID
– HY-129119
Shipping
– Room temperature
Molecular Formula
– C40H43N7O2
References
– [1]Zhao Z, et al. Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity. Bioorg Med Chem Lett. 2008 Jan 1;18(1):49-53.
CAS Number
– 612847-42-4
Molecular Weight
– 653.82
SMILES
– O=C(C1=CC=C2N=C(C3=CC=CC=C3)C(C4=CC=C(CN5CCC(N6C7=CC=CC=C7NC6=O)CC5)C=C4)=NC2=C1)NCCN(CC)CC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Akt;Caspase
Isoform
– Akt1;Akt2;Akt3;Caspase 3
Pathway
– Apoptosis;PI3K/Akt/mTOR
Product type
– Reference compound
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