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IC261
$80 – $350
Products Details
Product Description
– IC261 is a selective, ATP-competitive CK1 inhibitor, with IC50s of 1 μM, 1 μM, 16 μM for Ckiδ, Ckiε and Ckiα1, respectively.
Web ID
– HY-12774
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C18H17NO4
References
Р[1]Mashhoon N, et al. Crystal structure of a conformation-selective casein kinase-1 inhibitor. J Biol Chem. 2000 Jun 30;275(26):20052-60.|[2]Sțter M, et al. Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells. Oncogene. 2005 Dec 1;24(54):7964-75.|[3]Brockschmidt C, et al. Anti-apoptotic and growth-stimulatory functions of CK1 delta and epsilon in ductal adenocarcinoma of the pancreas are inhibited by IC261 in vitro and in vivo. Gut. 2008 Jun;57(6):799-806.
CAS Number
– 186611-52-9
Molecular Weight
– 311.33
Compound Purity
– 99.75
SMILES
– O=C1NC2=C(C=CC=C2)/C1=CC3=C(OC)C=C(OC)C=C3OC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : ≥ 33 mg/mL
Target
– Apoptosis;Casein Kinase
Isoform
– CK1
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
