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Piribedil
$38 – $340
Products Details
Product Description
– Piribedil is a potent and orally active dopamine D2 and dopamine D3 agonist. Piribedil is also a α2-adrenoceptors antagonist. Piribedil can inhibit MLL1 methyltransferase activity (EC50: 0.18 μM). Piribedil has the potential for the research of parkinson’s disease, circulatory disorders, cancers[1][2][3][4].
Web ID
– HY-12707
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C16H18N4O2
References
– [1]Sweet RD, et al. Piribedil, a dopamine agonist, in Parkinson’s disease. Clin Pharmacol Ther. 1974 Dec;16(6):1077-82. |[2]Gerlach M, et al. The effect of piribedil on L-DOPA-induced dyskinesias in a rat model of Parkinson’s disease: differential role of α(2) adrenergic mechanisms. J Neural Transm (Vienna). 2013 Jan;120(1):31-6. |[3]Smith LA, Tet al. Repeated administration of piribedil induces less dyskinesia than L-dopa in MPTP-treated common marmosets: a behavioural and biochemical investigation. Mov Disord. 2002 Sep;17(5):887-901.|[4]Xiong Zhang, et al. Piribedil disrupts the MLL1-WDR5 interaction and sensitizes MLL-rearranged acute myeloid leukemia (AML) to doxorubicin-induced apoptosis. Cancer Lett. 2018 Sep 1;431:150-160.
CAS Number
– 3605-01-4
Molecular Weight
– 298.34
Compound Purity
– 99.33
SMILES
– C1(N2CCN(CC3=CC=C(OCO4)C4=C3)CC2)=NC=CC=N1
Clinical Information
– Launched
Research Area
– Cancer; Endocrinology; Neurological Disease
Solubility
– DMSO : 33.33 mg/mL (ultrasonic)
Target
– Adrenergic Receptor;Dopamine Receptor;Histone Methyltransferase
Isoform
– D2 Receptor;D3 Receptor;α adrenergic receptor
Pathway
– Epigenetics;GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
