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Products Details
Product Description
– NR1H4 activator 1 is a potent and selective Famesoid X Receptor (FXR) agonist, extracted from patent WO2018152171A1, example 4. NR1H4 activator 1 shows strong FXR agonistic potency with a EC50 value of 1 nM in a Human FXR (NR1H4) Assay. NR1H4 activator 1 has the potential for treatment of gastrointestinal disease[1].
Web ID
– HY-125996
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C34H53NO7S
References
– [1]Guoqiang Wang, et al. Bile acid derivatives as fxr agonists and methods of use thereof. Patent WO2018152171A1.
CAS Number
– 2242855-68-9
Molecular Weight
– 619.85
SMILES
– C[C@@]12[C@@H]([C@H](C)COC(NS(=O)(C3=CC=C(OC(C)C)C=C3)=O)=O)CC[C@@]1([H])[C@]4([H])[C@H](O)[C@H](CC)[C@]5([H])C[C@@H](O)CC[C@]5(C)[C@@]4([H])CC2
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– FXR
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
