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Ferutinin
$85 – $510
Products Details
Product Description
– Ferutinin, a natural terpenoid compound, is an estrogen receptor ERα agonist and estrogen ERβ-receptor agonist/antagonist with IC50s of 33.1 nM and 180.5 nM, respectively. Ferutinin acts as an electrogenic Ca2+-ionophore that increases calcium permeability of lipid bilayer membranes, mitochondria. Ferutinin possesses estrogenic, antitumor, antibacterial and antiinflammatory activities[1][2].
Web ID
– HY-125703
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C22H30O4
References
– [1]Kazuhiro Ikeda, et al. Terpenoids found in the umbelliferae family act as agonists/antagonists for ER(alpha) and ERbeta: differential transcription activity between ferutinine-liganded ER(alpha) and ERbeta. Biochem Biophys Res Commun. 2002 Feb 22;291(2):354-60. |[2]Tatsiana Ilyich, et al. Ferutinin Induces Membrane Depolarization, Permeability Transition Pore Formation, and Respiration Uncoupling in Isolated Rat Liver Mitochondria by Stimulation of Ca 2+-Permeability. J Membr Biol. 2018 Aug;251(4):563-572.
CAS Number
– 41743-44-6
Molecular Weight
– 358.47
Compound Purity
– 99.0
SMILES
– O=C(O[C@@H]1[C@@]2([H])[C@@](C(C)C)(O)CC[C@]2(C)CC=C(C)C1)C3=CC=C(O)C=C3
Clinical Information
– No Development Reported
Research Area
– Cancer; Infection; Endocrinology; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Estrogen Receptor/ERR
Isoform
– ERα;ERβ
Pathway
– Apoptosis;Vitamin D Related/Nuclear Receptor
Product type
– Natural Products
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
