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Products Details
Product Description
– SHP844 is a SHP2 inhibitor with the IC50 of 18.9 µM. SHP2 is a protein tyrosine phosphatase (PTP) that regulates tyrosine phosphorylation levels and is involved in cell proliferation, differentiation and survival[1].
Web ID
– HY-125260
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C29H24ClN5O6
References
– [1]Michelle Fodor, et al. Dual Allosteric Inhibition of SHP2 Phosphatase. ACS Chem Biol. 2018 Mar 16;13(3):647-656.Â
CAS Number
– 2222280-82-0
Molecular Weight
– 573.98
SMILES
– O=C(O)[C@H]1N(C(C2=CC=C(CN3C4=NN=C(C5=CC=CC(OC)=C5O)N4C6=C(C=CC=C6)C3=O)C(Cl)=C2)=O)CCC1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– SHP2
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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