Download Files:
SPDB-DM4
$420 – $1,800
Products Details
Product Description
– SPDB-DM4 is a agent-linker conjugate for ADC by using the maytansinebased payload (DM4, a tubulin inhibitor) via a SPDB linker, exhibiting potent anti-tumor activity.
Web ID
– HY-12460
Storage Temperature
– -80°C, protect from light, stored under nitrogen
Shipping
– Dry Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C46H63ClN4O14S2
References
– [1]Puja Sapra, et al. Investigational antibody drug conjugates for solid tumors. Expert Opin Investig Drugs. 2011 Aug;20(8):1131-49.
CAS Number
– 1626359-62-3
Molecular Weight
– 995.59
Compound Purity
– 99.91
SMILES
– C[C@]1([C@H](CC(N(C(C=C2C=C3OC)=C3Cl)C)=O)OC([C@H](C)N(C)C(CCC(C)(C)SSCCCC(ON(C4=O)C(CC4)=O)=O)=O)=O)[C@H]([C@@H]([C@](OC5=O)([H])C[C@]([C@](/C=C/C=C(C)/C2)([H])OC)(N5)O)C)O1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : ≥ 300 mg/mL
Target
– Drug-Linker Conjugates for ADC
Isoform
– Maytansinoids
Pathway
– Antibody-drug Conjugate/ADC Related
Product type
– ADC Related
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
