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Products Details
Product Description
– JNJ 10329670 is a potent and selective noncovalent cathepsin S inhibitor with a Ki value of 34 nM for human cathepsin S. JNJ 10329670 blocks invariant chain proteolysis in B cells and dendritic cells, as well as antigen-induced T cell proliferation[1].
Web ID
– HY-123531
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C30H34ClF3N6O3S
References
– [1]Thurmond RL, et, al. Identification of a potent and selective noncovalent cathepsin S inhibitor. J Pharmacol Exp Ther. 2004 Jan;308(1):268-76.
CAS Number
– 400797-24-2
Molecular Weight
– 651.14
SMILES
– FC(F)(F)C1=CC=C(C=C1)C2=NN(C3=C2CN(CC3)S(=O)(C)=O)CCCN4CCC(CC4)N5C6=CC(Cl)=CC=C6N(C5=O)C
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Cathepsin
Isoform
– Cathepsin S
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
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