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PEAQX (tetrasodium hydrate)
$144 – $768
Products Details
Product Description
– PEAQX (NVP-AAM077) tetrasodium hydrate is a potent, selective and orally active NMDA antagonist, with IC50 values of 270 nM and 29600 nM for hNMDAR 1A/2B and hNMDAR 1A/2B, respectively[1].
Web ID
– HY-12294A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C17H15BrN3Na4O6P
Citations
– Am J Hypertens. 2021 Apr 15;hpab047.|Cells. 2023 Apr 22, 12(9), 1212.|Front Neurosci. 2021; 15: 703044.|J Clin Invest. 2019 Sep 3;129(9):3864-3876.|Neuroscience. 2018 Nov 1;391:1-12.
References
– [1]Qian Xu, et al. Sigma-1 receptor in brain ischemia/reperfusion: Possible role in the NR2A-induced pathway to regulate brain-derived neurotrophic factor. J Neurol Sci. 2017 May 15;376:166-175.|[2]Auberson YP, et al. 5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1099-102.|[3]Anastasio NC, et al. Differential role of N-methyl-D-aspartate receptor subunits 2A and 2B in mediating phencyclidine-induced perinatal neuronal apoptosis and behavioral deficits. Neuroscience. 2009 Nov 10;163(4):1181-91.
Molecular Weight
– 560.15
Compound Purity
– 98.0
SMILES
– BrC1=CC=C([C@H](C)NC(P(O[Na])(O[Na])=O)C2=CC=CC3=C2N=C(O[Na])C(O[Na])=N3)C=C1.[H]O[H]
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– H2O : 25.5 mg/mL (ultrasonic;warming)
Target
– Apoptosis;iGluR
Isoform
– NMDA Receptor
Pathway
– Apoptosis;Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
