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Products Details
Product Description
– BCL6 PROTAC 1 is a selective B-cell lymphoma 6 (BCL6) PROTAC. BCL6 PROTAC 1 inhibits BCL6 cell reporter with an IC50 value of 8.8 µM. BCL6 PROTAC 1 significantly degrades BCL6 in diffuse large B-cell lymphoma (DLBCL) cell lines. BCL6 PROTAC 1 can be used in tumor related research[1].
Web ID
– HY-122829
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C45H52ClN9O12
References
– [1]McCoull W, et al. Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6. ACS Chem Biol. 2018 Nov 16;13(11):3131-3141.
CAS Number
– 2257479-54-0
Molecular Weight
– 946.40
SMILES
– O=C(N1)C(N2C(C(C(OCCOCCOCCCNC(CCC(N3CCN(C4=NC=C(Cl)C(N5)=N4)[C@@H](COCCOC6=CC5=CC(CC7)=C6N(C)C7=O)C3)=O)=O)=CC=C8)=C8C2=O)=O)CCC1=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Bcl-2 Family;PROTACs
Pathway
– Apoptosis;PROTAC
Product type
– Reference compound
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