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SNIPER(ER)-110
SKU
HY-122825-Get quote
Category Reference compound
Tags Cancer, Estrogen Receptor/ERR;SNIPERs, PROTAC;Vitamin D Related/Nuclear Receptor
Products Details
Product Description
– SNIPER(ER)-110 consists of a IAP ligand and an estrogen ligand, connected by a linker. SNIPER(ER)-51 induces estrogen receptor (ER) protein degradation with DC50s of <3 nM and 7.7 nM after 4 h and 48 h, respectively[1].
Web ID
– HY-122825
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C66H83N5O11
References
– [1]Ohoka N, et al. Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation. J Biol Chem. 2018 May 4;293(18):6776-6790.
CAS Number
– 2241690-03-7
Molecular Weight
– 1122.39
SMILES
– O=C([C@H]1N(C([C@H](C2CCCCC2)NC([C@@H](NC)C)=O)=O)C[C@@H](OC3=CC=CC(OCCOCCOCCOCC(N(C)CCOC4=CC=C(/C(C5=CC=C(O)C=C5)=C(C6=CC=CC=C6)/CC)C=C4)=O)=C3)C1)N[C@@H]7CCCC8=C7C=CC=C8
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Estrogen Receptor/ERR;SNIPERs
Pathway
– PROTAC;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.